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IN THIS ISSUE:
October 2017

PANDAS
In a large, population-based cohort study, streptococcal infections were associated with an increased risk of childhood obsessive-compulsive disorder (OCD) and tic disorders.

Mortality in Schizophrenia: Do Antipsychotics Increase the Risk?
Treatment with antipsychotics appears to decrease the long-term risk of mortality in adults with schizophrenia.

Suvorexant (Belsomra) to Prevent Delirium?
Compared with placebo, suvorexant (Belsomra) decreased the risk of delirium in one study of elderly hospitalized patients.

Lithium Risks in Pregnancy
Lithium use during the first trimester of pregnancy can raise the chances of cardiac malformations in babies, but the risk is much lower than previously believed.

In Brief
Oxytocin May Help Treat Negative Symptoms of Schizophrenia but Seems to Have No Effect on Social Cognitive Function; Rates of Suicide among US Teens Have Increased Dramatically Since 2007

Bipolar Depression: Ongoing Search for New Avenues
Adjunctive dopamine-enhancing agents may merit a role in treatment algorithms for bipolar depression, but no benefit was found for the glutamatergic modulator riluzole (Rilutek).

Bipolar Depression: Ongoing Search for New Avenues

October 2017

In the lifetime course of bipolar disorder, mania and hypomania are more likely than depression to come to family, clinical, and societal attention. But depressive episodes and subsyndromal depressive symptoms usually dominate the course of the illness and are more likely to predict functional outcomes…

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