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IN THIS ISSUE:
October 2017

PANDAS
In a large, population-based cohort study, streptococcal infections were associated with an increased risk of childhood obsessive-compulsive disorder (OCD) and tic disorders.

Mortality in Schizophrenia: Do Antipsychotics Increase the Risk?
Treatment with antipsychotics appears to decrease the long-term risk of mortality in adults with schizophrenia.

Suvorexant (Belsomra) to Prevent Delirium?
Compared with placebo, suvorexant (Belsomra) decreased the risk of delirium in one study of elderly hospitalized patients.

Lithium Risks in Pregnancy
Lithium use during the first trimester of pregnancy can raise the chances of cardiac malformations in babies, but the risk is much lower than previously believed.

In Brief
Oxytocin May Help Treat Negative Symptoms of Schizophrenia but Seems to Have No Effect on Social Cognitive Function; Rates of Suicide among US Teens Have Increased Dramatically Since 2007

Bipolar Depression: Ongoing Search for New Avenues
Adjunctive dopamine-enhancing agents may merit a role in treatment algorithms for bipolar depression, but no benefit was found for the glutamatergic modulator riluzole (Rilutek).

Suvorexant (Belsomra) to Prevent Delirium?

October 2017

Orexin neurons help the brain maintain wakefulness and then fall silent during sleep. Decreased orexin signaling might underlie narcolepsy. Since antiquity, people have sought nostrums to promote sleep, and drugs that block orexin neuropeptides from binding to their receptors have been explored as…

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