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August 2014

Long-Acting Injectable Antipsychotics
The choice of whether or not to prescribe a long-acting injectable antipsychotic and, if so, which one to choose, should be based on the patient's ability to adhere to a oral medication regimen, individualized estimated risks and benefits, and cost.

Antidepressants and Suicidal Behavior: Effects of Dose and Age
For patients prescribed antidepressants, initiating treatment with higher doses may increase the risk of suicidal ideation and behavior in younger but not older patients.

In Brief
Girls with Anorexia Nervosa Have Increased Risk of Fractures; PTSD and Use of Antidepressants and Benzodiazepines during Pregnancy Increase Risk of Preterm Birth

Ramelteon (Rozerem)
Ramelteon (Rozerem) shows benefit for adults with insomnia in some trials, but the studies have been mostly short-term and the magnitude of difference compared with placebo has been small.

Ramelteon (Rozerem)

August 2014

A selective melatonin-receptor agonist approved by the FDA for the long-term treatment of insomnia, ramelteon (Rozerem) is unique among hypnotic agents. Unlike benzodiazepines and the "Z-drugs" (eg, zolpidem [Ambien and others], zaleplon [Sonata], and eszopiclone [Lunesta]), which bind to GABA receptors,…

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