July 2013

SSRI Risks during Surgery
Perioperative treatment with a selective serotonin reuptake inhibitor (SSRI) appears to increase the risk of adverse surgical outcomes.

Health Literacy and Antidepressant Adherence
Patients with limited health literacy have significantly worse adherence to antidepressant treatment than patients without this limitation.

Psychiatric Patients Can Quit Smoking
Studies of patients with schizophrenia, depression, or a related disorder show that quitting smoking does not increase the likelihood of recurrence or worsening psychiatric symptoms.

Folate Augmentation in Schizophrenia
A large multisite study found that folate supplementation in schizophrenia improves negative symptoms more than placebo in subjects with a functional genetic variant in enzymes that regulate folate absorption and metabolism.

In Brief
Depression Is a Risk Factor for Stroke in Middle-aged Women; Biomarker for Schizophrenia Obtained from Olfactory Epithelium

First Treatments for Depression: Benefits of a "Stepped" Approach
Low-intensity interventions are a reasonable first treatment option for patients with depression across the full range of symptom severity.

Antipsychotics Increase the Risk of Venous Thromboembolism
In a nested case-control study, current antipsychotic use was associated with an increased risk of venous thromboembolism.

Folate Augmentation in Schizophrenia

July 2013

Folate is a B vitamin that provides methyl donors for biosynthetic methylation reactions. Many of these reactions affect brain function, such as the synthesis of neurotransmitters. Folate also contributes to gene expression through methylation of DNA and histones.

Folate deficiency might heighten…

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