May 2013

Iloperidone Increases QTc
Coadministration of drugs that inhibit cytochrome P450 2D6 or 3A4 increases the potential for iloperidone (Fanapt) to prolong the QTc interval.

Diabetes and Dyslipidemia: Risks for Adolescents with Mental Illness
A retrospective cohort study found that adolescents with schizophrenia or bipolar disorder had higher rates of both diabetes and dyslipidemia.

Memantine for FTD: A Negative Study
In a double-blind, parallel-group study, memantine (Namenda) produced no benefit greater than placebo for patients with frontotemporal dementia but more frequent cognitive adverse events.

Inappropriate Sexual Behavior in FTD: A Case Report
Aripiprazole (Abilify) reduced inappropriate sexual behavior in an elderly man with frontotemporal dementia.

In Brief
Age and Dose Play a Role in the Effects of Antidepressants on Fracture Risk; Weight Management Intervention Program Beneficial for Patients with Schizophrenia

Hypertension following SSRI Withdrawal
A woman with depression experienced hypertension when citalopram (Celexa and others) was abruptly discontinued.

In Brief

May 2013

Antidepressants, especially serotonergic ones, are associated with an increased risk of fractures (BTP 2013;6:17-18). New reports from Norway and Denmark provide more data on this association. Bakken and colleagues conducted a nationwide prospective cohort study of 906,422 people in Norway…

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