May 2013

Iloperidone Increases QTc
Coadministration of drugs that inhibit cytochrome P450 2D6 or 3A4 increases the potential for iloperidone (Fanapt) to prolong the QTc interval.

Diabetes and Dyslipidemia: Risks for Adolescents with Mental Illness
A retrospective cohort study found that adolescents with schizophrenia or bipolar disorder had higher rates of both diabetes and dyslipidemia.

Memantine for FTD: A Negative Study
In a double-blind, parallel-group study, memantine (Namenda) produced no benefit greater than placebo for patients with frontotemporal dementia but more frequent cognitive adverse events.

Inappropriate Sexual Behavior in FTD: A Case Report
Aripiprazole (Abilify) reduced inappropriate sexual behavior in an elderly man with frontotemporal dementia.

In Brief
Age and Dose Play a Role in the Effects of Antidepressants on Fracture Risk; Weight Management Intervention Program Beneficial for Patients with Schizophrenia

Hypertension following SSRI Withdrawal
A woman with depression experienced hypertension when citalopram (Celexa and others) was abruptly discontinued.

Memantine for FTD: A Negative Study

May 2013

Second only to Alzheimer disease (AD) in prevalence, frontotemporal dementia (FTD) accounts for about 20% of pre-senile dementia cases.1 FTD results from progressive frontal lobe deterioration which, over time, may advance to the temporal lobes. Symptoms typically begin between ages 45…

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