March 2013

Adjunctive L-methylfolate for Treatment-Resistant Depression
L-methylfolate may be effective and well tolerated as an adjunctive treatment for depression, but questions remain about its safety and cost.

Antidepressants and the Risk of Breast Cancer
Current data suggest that women who take antidepressants do not have an increased risk of breast cancer.

Antipsychotics and Mortality in Schizophrenia
In general, adherence to antipsychotic treatment seems to decrease the risk of mortality in patients with schizophrenia, but high doses may increase the risk, regardless of adherence.

In Brief
FDA Recommends Decreased Bedtime Dose of Zolpidem for Women; Hearing Loss Linked to Cognitive Decline

Clozapine: Monitoring for Hazards
In addition to agranulocytosis, clozapine (Clozaril and others) can cause three other potentially lethal effects: diabetic ketoacidosis, gastrointestinal hypomotility, and myocarditis.

In Brief

March 2013

On January 10, the US FDA recommended that bedtime doses of zolpidem (Ambien and others) be decreased for women and considered for a decrease in men as well (US Food and Drug Administration. Available at:

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