February 2013

Duloxetine: How Does It Compare with Other Antidepressants?
For the acute treatment of depression, duloxetine (Cymbalta) is less well tolerated than less expensive medications that are equal in efficacy.

Psychotropics and MVA Risk
Drugs that affect the central nervous system—such as benzodiazepines, hypnotics, and some antidepressants—can impair cognitive and motor functions and thus increase the risk of accidents and injuries.

Risperidone for Agitation and Aggression in Alzheimer Disease
For patients with Alzheimer disease who respond to treatment with risperidone (Risperdal and others) for agitation and aggression, discontinuing the medication after 4 to 8 months increases the risk for relapse.

UTIs Can Trigger Acute Schizophrenia Relapse
Acute medical conditions, such as urinary tract infections, can trigger relapses in patients with schizophrenia.

In Brief
Exposure to Air Pollution Appears to Elevate Risk of Autism; Diagnosis of Gastritis is Associated with Increased Odds of Mood and Anxiety Disorders

Clozapine for Treatment-Resistant Bipolar Disorder
A retrospective analysis indicates that clozapine (Clozaril and others) may be efficacious for patients with treatment-resistant bipolar disorder.

ADHD Medication and Criminality
Treating attention-deficit/hyperactivity disorder (ADHD) with medications such as methylphenidate (Ritalin and others) or atomoxetine (Strattera) appears to reduce the rate of criminal behavior in patients.

Risperidone for Agitation and Aggression in Alzheimer Disease

February 2013

In recent years, a great deal of attention has been paid to the risks of prescribing antipsychotics to patients with dementia, including an increase in mortality approximately 1.7 times greater than with placebo. The US FDA requires a black box warning about this risk on these medications, and US…

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