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November 2012

Metformin to Counteract Antipsychotic Side Effects
A recent study adds to growing evidence that metformin (Glucophage and others) attenuates antipsychotic-induced side effects such as weight gain, insulin resistance, and amenorrhea.

Pioglitazone (Actos): A New Adjunct for MDD?
Pioglitazone (Actos) shows promise as an adjunctive treatment for depression.

Selenium and Depression
Low dietary selenium intake may increase the risk of depression.

Tablet Splitting
Tablet splitting can be convenient and save money but results vary depending on the patient and the pill.

Depression in CHF Patients: Benefits of Exercise
In a large study of patients with congestive heart failure, aerobic exercise was associated with small decreases in depression, hospitalization, and death.

In Brief
Anxiolytic Effects of Exercise Persist Despite Arousing Stimuli; Children of Parents with Mood Disorders Have Increased Risk of Mood Disorders

Pioglitazone (Actos): A New Adjunct for MDD?

November 2012

A newly recognized neuronal receptor, peroxisome proliferator-activated nuclear receptor (PPAR)-gamma belongs to a family of nuclear receptor transcription factors. PPAR-gamma has important anti-inflammatory, neuroprotective, anti-oxidative, and anti-excitotoxic properties, and its natural or synthetic…

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