August 2012

Exercise to Combat Sexual Side Effects?
In a small study, exercise before visual sexual stimuli increased arousal in antidepressant-treated women.

Lithium Toxicity
Despite potentially serious adverse effects, lithium may be the best treatment for some patients with bipolar disorder.

Donepezil and Memantine for Alzheimer Disease
In patients with Alzheimer disease, if donepezil (Aricept and others) is discontinued, memantine (Namenda) may improve cognition and function, but combining these two medications does not appear to add benefit to taking donepezil alone.

In Brief
Low Cardiovascular Fitness at Age 18 Years Associated with Later Depression; Literature Review Finds No Benefit of Omega-3 Fatty Acids in Prevention of Cognitive Decline

Cholinesterase Inhibitors and Hip Fracture Risk
A case-control analysis found that patients with Alzheimer disease who were taking cholinesterase inhibitors had an almost 60% lower risk of a hip fracture than those not taking one of these agents.

Treating Depression in Parkinson Disease
A recent study suggests that modern selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRI) are efficacious in patients with Parkinson disease and depression and unlikely to worsen motor function.

Donepezil and Memantine for Alzheimer Disease

August 2012

This year in the United States, the direct costs of caring for patients with Alzheimer disease (AD) and other forms of dementia is projected to reach $200 billion.1 The drug most frequently prescribed to treat AD is the cholinesterase inhibitor donepezil (Aricept and others), approved by…

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