July 2012

Two New Formulations of Zolpidem: Sublingual Tablet and Oral Spray
Two new formulations of zolpidem (Ambien and others) have been approved by the US Food and Drug Administration.

Do Antidepressants Cause Hypertension in Pregnancy?
A case-control study found evidence that antidepressants, and selective serotonin reuptake inhibitors (SSRIs) in particular, increase the risk of hypertension when taken during pregnancy.

Antipsychotics and MI Risk in Dementia
Antipsychotics may cause a transient increased risk of myocardial infarction in elderly patients with dementia.

In Brief
No Benefit from Adjunctive Modafinil for Patients with Alzheimer Disease; Extramedical Use of Prescription Pain Relievers Peaks in 16-year-olds

More on DBS for Treatment-Resistant Depression
In patients with treatment-resistant depression, deep brain stimulation to the subcallosal cingulate was associated with decreased depression scores and increased function.

Do Antidepressants Cause Hypertension in Pregnancy?

July 2012

An estimated 14% of pregnant women use antidepressants. Selective serotonin reuptake inhibitors (SSRIs) affect the handling of serotonin outside as well as inside the brain. Serotonin-norepinephrine reuptake inhibitors (SNRIs) have noradrenergic properties, both centrally and peripherally. Therefore,…

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