June 2012

Antipsychotics and Deaths in Nursing Homes
Second-generation antipsychotics can cause an increased risk of death in older patients with dementia. Mortality may increase with higher doses. Quetiapine might be safer than other drugs.

Persistent Pulmonary Hypertension in the Newborn: SSRIs Appear to Increase Risk
In a population-based cohort study, findings support other evidence associating an increased risk of PPHN with SSRI antidepressant use late in pregnancy.

Augmenting Clozapine
In patients with schizophrenia who are refractory to or intolerant of clozapine treatment, the use of an additional antipsychotic might be considered, although benefits are likely to be modest, and patients should be monitored closely.

Olanzapine-Induced Weight Gain and Metabolic Changes
When treated with olanzapine, adolescents appear to gain more weight than adults do.

In Brief
Comorbid Depression and Diabetes Increases Risk of Dementia; Long-Acting Injectable Risperidone (Risperdal Consta) Is Not Cost-Effective

Olanzapine-Induced Weight Gain and Metabolic Changes

June 2012

The second-generation antipsychotic olanzapine (Zyprexa and others) is a very popular agent and now available in generic formulations. Early on, it became clear that olanzapine caused more weight gain, metabolic abnormalities, diabetes mellitus, and “the metabolic syndrome” than most other…

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