May 2012

Antidepressants and Bleeding during Surgery
In a retrospective case-control study, antidepressant treatment was associated with an increase in bleeding during spinal surgery.

Gastric Bypass Changes Antidepressant Pharmacokinetics
Patients who undergo gastric bypass surgery are at risk for reduced drug bioavailability postoperatively.

Long-Acting Injectable Antipsychotics: Second- versus First-Generation
Long-acting injectable risperidone (Risperdal Consta) does not appear to offer clinical benefit compared with older agents for most patients with schizophrenia.

In Brief
Dietary Trans Fatty Acids Are Associated with Behavioral Irritability and Aggression; Cerebrospinal Fluid Biomarkers Useful for Monitoring Anti-ß-amyloid Drugs in Alzheimer Disease

Antipsychotics Increase Mortality in Patients with Parkinson Disease
In a nested case-control study involving more than 5,000 subjects, antipsychotic treatment was associated with an increased risk of death for patients with Parkinson disease.

Memantine (Namenda) for Dementia in Down Syndrome
In a prospective, double-blind, random-assignment trial, adults with Down syndrome did not gain any benefit from treatment with the N-methyl-D-aspartate antagonist memantine (Namenda).

Long-Acting Injectable Antipsychotics: Second- versus First-Generation

May 2012

In recent years, second-generation agents have largely dominated antipsychotic therapy. Most antipsychotics are prescribed in oral forms. However, long-acting injectable antipsychotics have the advantage of an assured delivery system, which is not dependent on patients' daily compliance with oral…

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