March 2012

Music Has Charm
Added to standard treatment, music therapy administered by trained therapists can improve symptoms in patients with schizophrenia.

Second-Generation Antidepressants: Are All Created Equal?
A recent meta-analysis found no substantial differences in efficacy among second-generation antidepressants in the treatment of patients with major depressive disorder.

Perinatal SSRI Exposure: Does It Contribute to Autism?
Rat pups exposed pre- and postnatally to citalopram (Celexa and others) showed altered neuroanatomy and behaviors similar to patients with autism spectrum disorders.

What Works Best for Acute Mania?
For patients with acute mania, a meta-analysis found that antipsychotic drugs are significantly more effective than "mood stabilizers," but using these agents long-term in this population can be problematic.

In Brief
Antidepressants, Antipsychotics, Cardiac events

CME Reminder
Don't forget that March 31 is the deadline for returning your Continuing Medical Education Answer Sheet to earn up to 12.0 hours in category 1 credits. No CME answer sheet submissions will be accepted after March 31.

Antipsychotics, Antidepressants, and Sudden Cardiac Death
The use of antidepressants or antipsychotics in patients who have had an acute myocardial infarction increases the risk of sudden cardiac death, especially if the two agents are combined.

In Brief

March 2012

Alzheimer disease (AD) is characterized neuropathologically by ß-amyloid-containing plaques and neurofibrillary tangles composed of hyperphosphorylated forms of the tau protein. In early stages of the disease, abnormal tau accumulates in the entorhinal cortex (EC). In later stages, accumulation…

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