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January 2012

The Big D
Vitamin D deficiency may contribute to depression, but data on vitamin D supplementation as an adjunctive treatment are inconclusive.

Adjunctive Treatment for PTSD: A Negative Study with Risperidone
A study of adjunctive risperidone (Risperdal and others) in patients with antidepressant-resistant symptoms of posttraumatic stress disorder found it provided no added benefit over placebo.

SSRI-Statin Combination Elevates Blood Glucose
In a retrospective study, investigators found that concomitant administration of paroxetine (Paxil and others) and pravastatin (Pravachol and others) increased blood glucose in patients with and without diabetes.

In Brief
Valproate Prophylaxis Not Effective for Behavioral Problems Associated with Dementia; More Evidence that Fish Consumption Protects Memory

SSRIs Plus Warfarin or Antiplatelet Agents: Apparent Increase in Bleeding
Serotonergic drugs appear to increase the risk of bleeding and probably act synergistically with antiplatelet agents and warfarin (Coumadin and others).

SSRIs Plus Warfarin or Antiplatelet Agents: Apparent Increase in Bleeding

January 2012

Warfarin (Coumadin and others), commonly prescribed to prevent thromboembolism, has a narrow therapeutic index and requires close monitoring. If the anticoagulant effect rises too high, major bleeding and intracranial hemorrhage could result. If it falls too low, the chance of thrombosis increases.


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