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November 2011

St John's Wort in Minor Depression
In a double-blind trial, neither St John's wort nor citalopram (Celexa and others) was superior to placebo in the treatment of minor depression.

Parkinson Disease Psychosis and Antipsychotics
Data from a Veterans Affairs medical facility over 6 years show that antipsychotic prescribing for patients with Parkinson disease and psychosis does not reflect evidence-based best practice.

TD in Elderly Patients: Incidence with Risperidone and Olanzapine
A study of risperidone (Risperdal and others) and olanzapine (Zyprexa and others) in elderly patients found the risk of tardive dyskinesia to be less that that associated with first-generation agents.

In Brief
Paroxetine Elevates Blood Levels of Metoprolol; SRIs Plus CBT Superior to Medication Alone for OCD in Kids

Massage for GAD?
In a 12-week trial, therapeutic massage provided no additional benefit over control conditions for patients with generalized anxiety disorder.

Lithium to Prevent Dementia?
In patients with amnestic mild cognitive impairment, lithium treatment may help prevent progression to Alzheimer disease.

In Brief

November 2011

Paroxetine (Paxil and others) is a potent inhibitor of the cytochrome P450 (CYP) 2D6 isoenzyme, which plays a major role in metabolizing the blood pressure medication metoprolol (Lopressor). Parker and Soberman conducted a prospective, open-label, three-way crossover study to compare the effects of…

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