August 2011

ECT Devices and the Future of ECT
An FDA panel questions reclassifying electroconvulsive therapy machines as intermediate rather than highest risk medical devices, which could threaten the availability of ECT in the United States.

Ziprasidone for Bipolar Depression: A Negative Result
In a random-assignment trial, adjunctive ziprasidone was not superior to placebo in reducing depressive symptoms in patients with bipolar I disorder.

Exercise is Good
Exercise may protect against the development of depression and anxiety in people aged 60 years and older in a dose-dependent fashion.

In Brief
Duloxetine Associated with Slight Weight Increase in Long-Term Treatment; Cognitive Behavioral Therapy for Insomnia Decreases Suicidal Ideation; Patients with Amnestic Mild Cognitive Impairment Have Substantial Functional Deficits

Varenicline in Schizophrenia
Pilot data suggest varenicline might increase the likelihood of patients with schizophrenia achieving abstinence from smoking.

Depression in CHD Patients: SSRIs Can Help
In patients with coronary heart disease, selective serotonin reuptake inhibitors appear to be safe, to decrease depression, and to improve cardiac outcomes and survival.

Varenicline in Schizophrenia

August 2011

Many factors conspire against the health of people with schizophrenia. One is tobacco use. Patients with schizophrenia smoke more frequently than the general population and suffer many adverse health consequences.

Varenicline (Chantix), a selective partial agonist of alpha-2 beta-4 subunits…

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