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August 2011

In Brief
Duloxetine Associated with Slight Weight Increase in Long-Term Treatment; Cognitive Behavioral Therapy for Insomnia Decreases Suicidal Ideation; Patients with Amnestic Mild Cognitive Impairment Have Substantial Functional Deficits

Varenicline in Schizophrenia
Pilot data suggest varenicline might increase the likelihood of patients with schizophrenia achieving abstinence from smoking.

ECT Devices and the Future of ECT
An FDA panel questions reclassifying electroconvulsive therapy machines as intermediate rather than highest risk medical devices, which could threaten the availability of ECT in the United States.

Ziprasidone for Bipolar Depression: A Negative Result
In a random-assignment trial, adjunctive ziprasidone was not superior to placebo in reducing depressive symptoms in patients with bipolar I disorder.

Exercise is Good
Exercise may protect against the development of depression and anxiety in people aged 60 years and older in a dose-dependent fashion.

Depression in CHD Patients: SSRIs Can Help
In patients with coronary heart disease, selective serotonin reuptake inhibitors appear to be safe, to decrease depression, and to improve cardiac outcomes and survival.

In Brief

August 2011

Last year (BTP 2010;33:48-49), we reported that duloxetine (Cymbalta) caused weight loss during acute treatment of depression but had no effect on weight during long-term treatment. Further analyses confirm that duloxetine is associated with a small mean decrease in body weight (0.5 to 1.0…

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