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May 2011

Does LAIR Beat Oral Antipsychotics?
A study by Rosenheck et al failed to find long-acting injectable risperidone (Risperdal Consta) superior in efficacy to oral antipsychotics.

Healthy Diet/Healthy Heart/Healthy Brain?
People who eat more trans unsaturated fats may have an increased risk of depression.

In Brief
Prevalence of Eating Disorders in Adolescents; Gender Differences in Anxiety Disorders

Do Antidepressants Still Work?
From 1983 to 2008, the placebo-response rate in trials of antidepressants for major depressive disorder increased, while the effect size decreased.

Breast Cancer in Women with Schizophrenia: Approaches to Prevention
Compared with women in the general population, women with schizophrenia have even more risk factors for breast cancer, some of which are preventable.

Treatment-Resistant GAD: Little Evidence
For treatment-resistant generalized anxiety disorder, many treatment options have been tried, but few have been sufficiently studied.

Do Antidepressants Still Work?

May 2011

The first classes of modern antidepressant drugs, tricyclics and monoamine oxidase inhibitors, were introduced in the 1950s. Early trials showed them clinically and statistically superior to placebo. Over the years, however, the antidepressant effect in placebo-controlled trials appears to have waned.…

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