April 2011

Depression in Alzheimer Disease
Sertraline (Zoloft and others) offers little benefit for depression in patients with Alzheimer disease.

Do Beta-Blockers Cause Depression?
Propranolol (Inderal and others) and other lipid-soluble beta-blockers may cause depressive symptoms early in treatment.

Liquid Formulations of Psychotropics
Many psychotropic medications are available in liquid formulations, which increases clinical options.

L-theanine Augmentation for Schizophrenia
L-theanine augmentation is associated with modest improvement in schizophrenia symptoms.

Acupuncture for Depression?
A systematic evaluation of reviews of acupuncture for depression conclude that it is not superior to placebo.

In Brief
Deep brain stimulation treats hallucinations in patients with schizophrenia; Pimozide augmentation not effective for treatment-resistant schizophrenia

Second-Generation Antipsychotics for Depression and Anxiety
For both depression and anxiety, quetiapine (Seroquel) is efficacious as monotherapy and as an adjunct to antidepressants.

CME Reminder
Continuing Medical Education Assessment Questions are now due.

L-theanine Augmentation for Schizophrenia

April 2011

L-theanine is an amino acid in the tea plant, which can cross the blood-brain barrier. It has neuroprotective properties, perhaps related to the glutamate receptor and glutamate transporter. L-theanine also may inhibit excitatory neurotransmission and cause inhibitory neurotransmission. Hypothetically,…

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