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IN THIS MONTH'S ISSUE:
April 2015

Antidepressants and the Risk of a Manic Switch in Young Bipolar Patients
Current evidence suggests that antidepressants are associated with a substantially increased risk of precipitating a manic switch in children and adolescents with bipolar disorder.

Start Lithium Early?
Starting lithium early in the course of bipolar disorder appears to improve the probability of an excellent response to lithium.

New-Onset Cardiovascular Disease in Bipolar Disorder Patients
Patients with bipolar I or bipolar II disorder experience cardiovascular disease earlier in their lives and at a higher rate than the general population and than patients with major depressive disorder.

In Brief
Attention-Deficit/Hyperactivity Disorder (ADHD) Is Associated with Increased Mortality; Depressive, Anxiety, and Behavioral Disorders May Be Risk Factors for Bipolar Disorder

Antipsychotics and Mortality in Schizophrenia
Examining a nationwide cohort of patients with schizophrenia, investigators in Finland found that the highest risk of mortality was associated with no antipsychotic treatment, and the next highest risk came from high antipsychotic doses.

Anticholinergic Drugs for Dementia Patients
A majority of nursing home residents with dementia are treated with anticholinergic agents, which may counteract the benefits of acetylcholinesterase inhibitors and directly impair memory and cognition.

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