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IN THIS MONTH'S ISSUE:
September 2016

Antipsychotics, Antidepressants, Torsades de Pointes, and the Risk of Sudden Death
Some antipsychotics and antidepressants may elevate the risk of sudden death by prolonging the QT interval, especially in older patients and those with heart disease.

Pregabalin in Pregnancy
In one study of human exposure during pregnancy, pregabalin (Lyrica) was associated with an increased rate of congenital malformations.

Preventing MDD via the Web
For people with subthreshold depression, web-based, guided self-help strategies may decrease the risk of developing major depressive disorder.

In Brief
Escitalopram (Lexapro) Does Not Improve Clinical Outcome in Patients with Heart Failure and Depression; E-cigarette Use in Adolescents Is Associated with Increased Cigarette Smoking in Transition to Adulthood

Cataract Risk and Antipsychotics
In a nested case-control study, investigators found that neither first- nor second-generation antipsychotics were associated with the development of cataracts in patients with schizophrenia.

Antidepressants and Hyponatremia
Almost all antidepressants are associated with hyponatremia, and older patients are at greater risk.

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