November 2015

Brexpiprazole (Rexulti)
The manufacturer of aripiprazole (Abilify and others), which is now off patent, has released a similar drug called brexpiprazole (Rexulti), which the FDA has approved to treat schizophrenia and as an adjunct to antidepressants for major depressive disorder (MDD).

Medical Marijuana
Several recent reviews question the evidence for the efficacy of medical marijuana and caution about its potential long-term side effects.

In Brief
Vitamin D Deficiency Associated with Increased Cognitive Decline in Older Adults; High-Glycemic Diets Associated with Increased Risk of Depression in Postmenopausal Women

Nitrous Oxide for Depression?
A pilot study of nitrous oxide inhalation for patients with treatment-resistant depression has yielded positive results.

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