IN THIS MONTH'S ISSUE:
October 2014

ADHD, Stimulants, and Young Hearts
Stimulant medications, such as methylphenidate (Ritalin and others), are associated with a small increase in the risk of cardiovascular events in children and adolescents, and a slightly greater risk in those with attention-deficit/hyperactivity disorder (ADHD).

Estradiol for Schizophrenia?
In a double-blind, randomized, placebo-controlled trial, women with schizophrenia or schizoaffective disorder had a small but statistically significant improvement in previously treatment-resistant psychotic symptoms when treated with transdermal estradiol.

Rapid Clozapine Titration: Additional Comments
Some patients with schizophrenia may benefit from very gradual (rather than rapid) titration of clozapine (Clozaril and others), especially if they are taking concomitant benzodiazepines.

In Brief
Mindfulness Training Promotes Recovery from Stress in Military Personnel; Compound in Pomegranates May Help Slow Neurodegenerative Disorders

Pregnenolone for Bipolar Depression?
Adjunctive treatment with the neurosteroid pregnenolone may improve depressive symptoms in patients with bipolar disorder.

Allopurinol in Acute Mania?
Preliminary findings indicate benefit from adding allopurinol (Zyloprim and others) to valproate (Depakene and others) for the treatment of acute mania.

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