IN THIS MONTH'S ISSUE:
September 2014

Inhaled Loxapine
An inhalation powder formulation of loxapine (Adasuve) has been approved by the FDA to treat acute agitation resulting from schizophrenia or bipolar I disorder in adults.

Lithium in the Elderly
Elderly patients taking low doses of lithium to attenuate the course of Alzheimer disease experience more overall adverse effects than placebo-treated patients, most notably weight gain, diabetes mellitus, and cardiac arrhythmia.

Antipsychotic-Induced Weight Gain and Other Adverse Metabolic Effects: Purported Antidotes
When switching agents is not feasible and diet and exercise are ineffective, current evidence points to metformin (Glucophage and others) as the best antidote for antipsychotic-induced weight gain.

In Brief
Venlafaxine Recall Due to Dissolution Failure; Interventions to Reduce Smoking Are Associated with Decreases in Suicide Risk

SSRIs and QT Prolongation
A recent meta-analysis found varying degrees of QT interval prolongation among selective serotonin reuptake inhibitors (SSRIs).

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