IN THIS MONTH'S ISSUE:
January 2015

Vortioxetine (Brintellix): a "Multi-Modal Antidepressant"
The new selective serotonin reuptake inhibitor (SSRI) antidepressant vortioxetine (Brintellix) offers no proven superiority in efficacy or tolerability over older, less expensive, and better tested agents.

Topiramate and Long-term Weight Loss in Schizophrenia Patients
For obese patients with schizophrenia, the anticonvulsant topiramate (Topamax) appears to promote weight loss during treatment and for long after it is discontinued.

In Brief
Paliperidone Palmitate (Invega Sustenna) Approved by FDA for Schizoaffective Disorder; Chronic Marijuana Use Causes Structural Changes in the Brain

Risks of Antipsychotic Drugs in Older Patients
Antipsychotic treatment in elderly patients is associated with an increased risk of mortality and may contribute to acute kidney injury.

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