In your March, 2010 issue of BTP, I wrote an article on clozapine induced hypersalivation. In it I mentioned oral anticholinergics or alphaadrenergics as potential remedies.
“I start with one drop SL before bed. For some people, that is all they need. Other people need 24 drop SL qhs; some, in addition to their one drop SL qhs, put one drop into a small amount of water next to the bed, so if they wake at night drooling, they can drink that water and control the drooling for the remainder of the night. Most people don’t need it during the day, but some do use one or a few drops SL in the morning as well. The only side effect is dry mouth, if too much is used. No systemic side effects! People love it! They feel so much better getting off their oral, systemic anticholingic…Of course, it ALWAYS prompts a call from the pharmacy before the first Rx is filled, because giving an eye drop sublingually is pretty unusual.”