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IN THIS ISSUE:
August 2014

Long-Acting Injectable Antipsychotics
The choice of whether or not to prescribe a long-acting injectable antipsychotic and, if so, which one to choose, should be based on the patient's ability to adhere to a oral medication regimen, individualized estimated risks and benefits, and cost.

Antidepressants and Suicidal Behavior: Effects of Dose and Age
For patients prescribed antidepressants, initiating treatment with higher doses may increase the risk of suicidal ideation and behavior in younger but not older patients.

In Brief
Girls with Anorexia Nervosa Have Increased Risk of Fractures; PTSD and Use of Antidepressants and Benzodiazepines during Pregnancy Increase Risk of Preterm Birth

Ramelteon (Rozerem)
Ramelteon (Rozerem) shows benefit for adults with insomnia in some trials, but the studies have been mostly short-term and the magnitude of difference compared with placebo has been small.

Long-Acting Injectable Antipsychotics

August 2014

Schizophrenia is usually a lifelong disorder. Almost all patients require long-term maintenance antipsychotic therapy to lower the risk of psychotic decompensation. The likelihood of relapse in schizophrenia is increased by factors such as substance abuse and social stress, but a major cause is poor…

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