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IN THIS ISSUE:
June 2014

The Downside of Testosterone
Prescribed testosterone can be an effective medical intervention in selected cases of hypogonadism in men, but its use as a rejuvenator for all men appears unwarranted.

Agitation in Alzheimer Disease: a Role for an SSRI?
Citalopram (Celexa and others) seems to decrease agitation in patients with Alzheimer disease, but it may have adverse cardiac effects.

Renal Failure Risk with Lithium
The risk to kidney function from long-term treatment with lithium may be compounded by increasing patient age.

In Brief
GlaxoSmithKline Recalls Batches of Paroxetine for Possible Contamination; Marijuana Use Associated with Structural Brain Changes

Maintenance Antipsychotic Strategy: Highs and Lows
After remission is achieved on antipsychotic therapy after a first episode of schizophrenia, reducing or discontinuing the antipsychotic may have long-term benefits over standard-dose maintenance treatment.

Maintenance Antipsychotic Strategy: Highs and Lows

June 2014

For over a half century, antipsychotic drugs have been the mainstay of treatment for chronic psychotic conditions—most notably, schizophrenia. During this time, recommended dosing strategies have varied widely. In the 1970s, there was enthusiasm for prescribing ultra-high antipsychotic doses…

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