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IN THIS ISSUE:
May 2014

Pharmacokinetic Issues with Some Newer Antipsychotics
Complicated dosing requirements and bothersome side effects may contribute to findings of high discontinuation rates and low efficacy for some antipsychotics in clinical trials.

Rapid Clozapine Titration
Some patients with acute psychotic symptoms and difficult-to-treat schizophrenia can benefit from clozapine in a rapid-titration regimen.

Lisdexamfetamine Augmentation in MDD
Amphetamine augmentation of an antidepressant is an option for patients with difficult-to-treat major depressive disorder, especially those with executive dysfunction.

Hyperprolactinemia, Bone Loss, and Antipsychotic Drugs
In an open-label naturalistic study of patients with schizophrenia, there was a greater association between hyperprolactinemia and decreased bone density in men than in women.

In Brief
Sleep Loss May Cause Irreversible Brain Injury; Parental Age Affects Risk for Psychiatric Disorders in Offspring

UTIs in Acute Psychosis
A recent study suggests that acute psychotic episodes across a wide range of psychiatric diagnoses can be triggered by urinary tract infections.

UTIs in Acute Psychosis

May 2014

We regularly observe that patients with schizophrenia die at a younger age than the general population. Among other variables that contribute to increased mortality, patients with this disorder suffer more infections throughout their lives, possibly based on immune abnormalities.

Infection can…

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