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March 2014

Antipsychotics in Children and Adolescents: Effects on Weight, Metabolism, and Prolactin
Metabolic effects of antipsychotics in children are similar to those in adults but potentially more damaging because of longer treatment duration.

Antipsychotic-Induced Hyperprolactinemia: Adjunctive Aripiprazole Helps
A meta-analysis of studies of adjunctive aripiprazole (Abilify) for antipsychotic-induced hyperprolactinemia showed significant benefit over placebo in normalizing prolactin levels.

Long-Acting Injectable Second-Generation Antipsychotics
A recent paper reviews delivery methods, dosing, pharmacokinetics, and side effects of the four second-generation long-acting injectable antipsychotics.

In Brief
Prevalence Estimates for Autism Spectrum Disorder May Be Lower with New Criteria in the DSM-5; Individuals with Severe Psychotic Illness Are at Increased Risk of Smoking and Alcohol and Drug Use

Antipsychotic-Induced Hyperprolactinemia: Adjunctive Aripiprazole Helps

March 2014

Typical antipsychotic drugs are potent D2 dopamine receptor blockers, which means that they often raise plasma levels of the pituitary hormone prolactin. First-generation antipsychotics and risperidone (Risperdal and others) are the antipsychotics most commonly associated with hyperprolactinemia,…

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