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IN THIS ISSUE:
March 2014

Antipsychotics in Children and Adolescents: Effects on Weight, Metabolism, and Prolactin
Metabolic effects of antipsychotics in children are similar to those in adults but potentially more damaging because of longer treatment duration.

Antipsychotic-Induced Hyperprolactinemia: Adjunctive Aripiprazole Helps
A meta-analysis of studies of adjunctive aripiprazole (Abilify) for antipsychotic-induced hyperprolactinemia showed significant benefit over placebo in normalizing prolactin levels.

Long-Acting Injectable Second-Generation Antipsychotics
A recent paper reviews delivery methods, dosing, pharmacokinetics, and side effects of the four second-generation long-acting injectable antipsychotics.

In Brief
Prevalence Estimates for Autism Spectrum Disorder May Be Lower with New Criteria in the DSM-5; Individuals with Severe Psychotic Illness Are at Increased Risk of Smoking and Alcohol and Drug Use

Antipsychotics in Children and Adolescents: Effects on Weight, Metabolism, and Prolactin

March 2014

Pediatric patients appear vulnerable to the same adverse effects of antipsychotic drugs that adults are, including weight gain, adverse metabolic effects, and prolactin elevation. But when an antipsychotic is started in a patient at a young age, it is likely to be continued for many years, and the…

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