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IN THIS ISSUE:
August 2013

Antipsychotics for MDD?
Adjunctive treatment with some antipsychotics may improve symptoms in patients with treatment-resistant depression but can cause considerable side effects.

ECT for Huntington Disease
In a small trial, electroconvulsive therapy (ECT) was associated with significant improvement in symptoms of Huntington disease.

Zolpidem Withdrawal Toxicity
Rapid dosage decreases of zolpidem (Ambien and others) can lead to delirium or seizures.

Clostridium Difficile Infection, Depression, and Antidepressants
Major depression and treatment with some antidepressants appear to contribute to the risk of Clostridium difficile infection.

In Brief
Two Patient Die After Treatment with Olanzapine Pamoate; Treatments for Attention-Deficit/Hyperactivity Disorder Not Linked to Later Substance Abuse; Patients with Migraines and Depression May Have Smaller Brain Size

When Generic Medication Changes in Appearance
When a patient is switched to a generic medication, changes in pill color and, to a lesser extent, shape from the brand name product can lead to nonadherence.

Benzodiazepines Plus Antipsychotics?
Although benzodiazepines do not appear to alleviate symptoms of schizophrenia, they can be safely administered to patients with psychotic disorders to alleviate anxiety, agitation, excitement, and insomnia.

Zolpidem Withdrawal Toxicity

August 2013

On January 10, the FDA lowered the recommended bedtime doses of zolpidem (Ambien and others) for women from 10 to 5 mg for the immediate-release formulation and from 12.5 to 6.25 mg for the extended-release product (BTP 2013;36:11). They advised considering lower doses for men as well. Reports…

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