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July 2013

Health Literacy and Antidepressant Adherence
Patients with limited health literacy have significantly worse adherence to antidepressant treatment than patients without this limitation.

Psychiatric Patients Can Quit Smoking
Studies of patients with schizophrenia, depression, or a related disorder show that quitting smoking does not increase the likelihood of recurrence or worsening psychiatric symptoms.

Folate Augmentation in Schizophrenia
A large multisite study found that folate supplementation in schizophrenia improves negative symptoms more than placebo in subjects with a functional genetic variant in enzymes that regulate folate absorption and metabolism.

In Brief
Depression Is a Risk Factor for Stroke in Middle-aged Women; Biomarker for Schizophrenia Obtained from Olfactory Epithelium

First Treatments for Depression: Benefits of a "Stepped" Approach
Low-intensity interventions are a reasonable first treatment option for patients with depression across the full range of symptom severity.

SSRI Risks during Surgery
Perioperative treatment with a selective serotonin reuptake inhibitor (SSRI) appears to increase the risk of adverse surgical outcomes.

Antipsychotics Increase the Risk of Venous Thromboembolism
In a nested case-control study, current antipsychotic use was associated with an increased risk of venous thromboembolism.

SSRI Risks during Surgery

July 2013

More than 200 million major surgical operations take place each year around the world.1 Surgery carries substantial risks: a recent study found a 30-day mortality rate of 1.9%.2

Selective serotonin reuptake inhibitors (SSRIs) are among the most commonly prescribed medications…

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