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IN THIS ISSUE:
June 2013

Carbamazepine Lowers Aripiprazole Levels
The US FDA has issued a warning that when carbamazepine (Tegretol and others) is added to an aripiprazole (Abilify) regimen, the dose of aripiprazole should be doubled.

QT Interval and Antidepressants
In a cross-sectional study, QT prolongation was associated with citalopram (Celexa and others), escitalopram (Lexapro and others), and amitriptyline (Elavil and others)—but not with other antidepressants.

Estrogen Augmentation for Women with Schizophrenia
In a small, double-blind trial, adding estrogen to an antipsychotic regimen improved scores on the Positive and Negative Syndrome Scale (PANSS) for women of childbearing age with chronic schizophrenia.

tDCS for Depression
Combining transcranial direct current stimulation (tDCS) with antidepressants may benefit patients with treatment-resistant depression, but there is little evidence for the efficacy of tDCS alone in this condition.

In Brief
Prenatal Valproate Linked to Increase in Childhood Autism; Hypertension Plus Genetic Risk Factors for Alzheimer Disease Increase ß-amyloid Deposition

Omega-3 Fatty Acids for Depression: Disappointing Results
A recent meta-analysis found no benefit of omega-3 fatty acid treatment for depression compared with placebo.

Carbamazepine Lowers Aripiprazole Levels

June 2013

In March 2013, the US FDA published a notification that the coadministration of carbamazepine (Tegretol and others) can substantially lower blood levels of aripiprazole (Abilify).

Aripiprazole is metabolized by two isoforms of cytochrome P450 (CYP): 3A4 and 2D6. Carbamazepine is a potent inducer…

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