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IN THIS ISSUE:
April 2013

Clozapine and Beyond
For patients with schizophrenia who do not respond to or cannot tolerate clozapine (Clozaril and others), olanzapine (Zyprexa and others) might be efficacious.

T3 Augmenting an SSRI for MDD: A Negative Trial
Several studies failed to find support for augmentation of antidepressant therapy with triiodothyronine (T3) in patients with major depressive disorder.

Hypersexuality in Dementia
For patients with dementia, the hormone modulator medroxyprogesterone acetate (MPA) may be effective for diminishing hypersexual behaviors.

Diet and Schizophrenia
Patients with schizophrenia typically have poor diets, which may increase cardiovascular risk factors.

Tamoxifen with Antidepressants
Women taking tamoxifen (Nolvadex and others) for estrogen-positive breast cancer should avoid concomitant treatment with antidepressants that inhibit the cytochrome P450 isoenzyme 2D6.

In Brief
Number of People with Alzheimer Disease to Triple in Next 40 Years; Abnormalities in Dorsolateral Prefrontal Cortex Correlate with Premenstrual Dysphoric Disorder

Driving and Antidepressants
Some antidepressants may impair driving ability.

Benzodiazepines, Pneumonia, and Mortality
In a large case-control analysis, benzodiazepines and zopiclone were associated with a 50% increase in the risk of contracting pneumonia and dying from it.

Antidepressants Increase Fracture Risk
In a recent meta-analysis, selective serotonin reuptake inhibitors (SSRIs) were associated with a higher increase in risk of bone fractures than tricyclic antidepressants.

Clozapine and GERD
Treatment with clozapine (Clozaril and others) may cause gastroesophageal reflux disease (GERD) in some patients.

Benzodiazepines, Pneumonia, and Mortality

April 2013

Approximately 2% of people in the United States and the United Kingdom take benzodiazepines each year—up to 10% in the elderly. Some animal and human studies suggest that benzodiazepines might increase susceptibility to infection, perhaps by activating GABAA receptors on immune cells.…

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