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IN THIS ISSUE:
July 2012

Two New Formulations of Zolpidem: Sublingual Tablet and Oral Spray
Two new formulations of zolpidem (Ambien and others) have been approved by the US Food and Drug Administration.

Do Antidepressants Cause Hypertension in Pregnancy?
A case-control study found evidence that antidepressants, and selective serotonin reuptake inhibitors (SSRIs) in particular, increase the risk of hypertension when taken during pregnancy.

Antipsychotics and MI Risk in Dementia
Antipsychotics may cause a transient increased risk of myocardial infarction in elderly patients with dementia.

In Brief
No Benefit from Adjunctive Modafinil for Patients with Alzheimer Disease; Extramedical Use of Prescription Pain Relievers Peaks in 16-year-olds

More on DBS for Treatment-Resistant Depression
In patients with treatment-resistant depression, deep brain stimulation to the subcallosal cingulate was associated with decreased depression scores and increased function.

Two New Formulations of Zolpidem: Sublingual Tablet and Oral Spray

July 2012

Countless people who have difficulty sleeping ask their doctors for "sleeping pills." For years, the most popular prescription hypnotic has been zolpidem (Ambien and others), a nonbenzodiazepine that acts as a benzodiazepine receptor agonist. (The pharmacologic, clinical, and adverse effects of these…

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