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May 2012

Antidepressants and Bleeding during Surgery
In a retrospective case-control study, antidepressant treatment was associated with an increase in bleeding during spinal surgery.

Gastric Bypass Changes Antidepressant Pharmacokinetics
Patients who undergo gastric bypass surgery are at risk for reduced drug bioavailability postoperatively.

Long-Acting Injectable Antipsychotics: Second- versus First-Generation
Long-acting injectable risperidone (Risperdal Consta) does not appear to offer clinical benefit compared with older agents for most patients with schizophrenia.

In Brief
Dietary Trans Fatty Acids Are Associated with Behavioral Irritability and Aggression; Cerebrospinal Fluid Biomarkers Useful for Monitoring Anti-ß-amyloid Drugs in Alzheimer Disease

Antipsychotics Increase Mortality in Patients with Parkinson Disease
In a nested case-control study involving more than 5,000 subjects, antipsychotic treatment was associated with an increased risk of death for patients with Parkinson disease.

Memantine (Namenda) for Dementia in Down Syndrome
In a prospective, double-blind, random-assignment trial, adults with Down syndrome did not gain any benefit from treatment with the N-methyl-D-aspartate antagonist memantine (Namenda).

Memantine (Namenda) for Dementia in Down Syndrome

May 2012

Today people with Down syndrome often survive into mid-life and beyond. Unfortunately, about 10% of those who live to age 40 develop Alzheimer disease (AD). Of people with Down syndrome who reach age 50, one in three develops AD, and the proportion rises to more than half in those older than 60 years.1


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