Second-Generation Antipsychotics for Bipolar Maintenance Treatment
Second-generation antipsychotics are commonly used in maintenance treatment for bipolar disorder, but data supporting this use are very limited.
Dosing Lithium and Olanzapine for Bipolar Maintenance
A post hoc analysis of data from a study of maintenance treatments for bipolar disorder suggests optimal lithium levels for the prevention of manic or mixed episodes and optimal olanzapine doses to protect against depressive episodes.
Constipation is a common and sometimes severe adverse effect of antipsychotic treatment for patients with schizophrenia, and it occurs with both first- and second-generation agents.
First-generation antipsychotics carry a considerable anticholinergic burden. Among anticholinergic side effects, constipation can be severe. Most second-generation antipsychotics are less potent blockers of the cholinergic-muscarinic receptor, but constipation is prevalent with these agents as well,…