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IN THIS ISSUE:
July 2011

Second-Generation Antipsychotics for Bipolar Maintenance Treatment
Second-generation antipsychotics are commonly used in maintenance treatment for bipolar disorder, but data supporting this use are very limited.

Dosing Lithium and Olanzapine for Bipolar Maintenance
A post hoc analysis of data from a study of maintenance treatments for bipolar disorder suggests optimal lithium levels for the prevention of manic or mixed episodes and optimal olanzapine doses to protect against depressive episodes.

Antipsychotic-Induced Constipation
Constipation is a common and sometimes severe adverse effect of antipsychotic treatment for patients with schizophrenia, and it occurs with both first- and second-generation agents.

Dosing Lithium and Olanzapine for Bipolar Maintenance

July 2011

In 2005, Tohen et al published a 12-month, randomized, double-blind, controlled clinical trial of olanzapine versus lithium as maintenance treatment for bipolar disorder.1 Patients who met remission criteria after open-label treatment with the combination of olanzapine and lithium were…

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