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IN THIS ISSUE:
July 2011

Second-Generation Antipsychotics for Bipolar Maintenance Treatment
Second-generation antipsychotics are commonly used in maintenance treatment for bipolar disorder, but data supporting this use are very limited.

Dosing Lithium and Olanzapine for Bipolar Maintenance
A post hoc analysis of data from a study of maintenance treatments for bipolar disorder suggests optimal lithium levels for the prevention of manic or mixed episodes and optimal olanzapine doses to protect against depressive episodes.

Antipsychotic-Induced Constipation
Constipation is a common and sometimes severe adverse effect of antipsychotic treatment for patients with schizophrenia, and it occurs with both first- and second-generation agents.

Second-Generation Antipsychotics for Bipolar Maintenance Treatment

July 2011

A majority of antipsychotic drug prescriptions in the United States are now written for patients with bipolar disorder. All second-generation agents, except iloperidone (Fanapt), paliperidone (Invega), and clozapine (Clozaril and others), are labeled by the US Food and Drug Administration (FDA) for…

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