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February 2010

Second-Generation Antipsychotics: New Information
Second-generation antipsychotics differ from each other, offering options for patients.

Cognitive Effects of Antipsychotic Drugs: Are All Created Equal?
First- and second-generation antipsychotics appear comparable in their ability to lessen cognitive dysfunction associated with schizophrenia.

In Brief
Long-acting Injectable Olanzapine Approved in US; High-potency Cannabis May Increase Risk of Psychosis

Olanzapine and Sertraline Combined for Psychotic Depression
In a short-term trial, sertraline (Zoloft and others) combined with olanzapine (Zyprexa) was more efficacious than olanzapine plus placebo for psychotic depression in both young and elderly patients.

Olanzapine and Sertraline Combined for Psychotic Depression

February 2010

Between 15% and 20% of patients with major depression may have psychotic features; in elderly depressed patients, the estimate climbs to almost 50%!1 When psychosis accompanies major depression, patients often take longer to recover from acute episodes and have worse short-term outcomes,…

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