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IN THIS ISSUE:
February 2010

Second-Generation Antipsychotics: New Information
Second-generation antipsychotics differ from each other, offering options for patients.

Cognitive Effects of Antipsychotic Drugs: Are All Created Equal?
First- and second-generation antipsychotics appear comparable in their ability to lessen cognitive dysfunction associated with schizophrenia.

In Brief
Long-acting Injectable Olanzapine Approved in US; High-potency Cannabis May Increase Risk of Psychosis

Olanzapine and Sertraline Combined for Psychotic Depression
In a short-term trial, sertraline (Zoloft and others) combined with olanzapine (Zyprexa) was more efficacious than olanzapine plus placebo for psychotic depression in both young and elderly patients.

Cognitive Effects of Antipsychotic Drugs: Are All Created Equal?

February 2010

Patients with schizophrenia tend to have lower cognitive performance on standardized psychometric tests than people without schizophrenia. Cognitive impairment, which is now considered a core symptom of the illness,1 often appears before the onset of psychosis, persists throughout a patient’s…

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