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IN THIS ISSUE:
December 2009

Cholinesterase Inhibitors Cause Syncope
Cholinesterase inhibitors, such as donepezil (Aricept), galantamine (Razadyne), and rivastigmine (Exelon), which are used to treat Alzheimer's disease, may cause syncope.

In Brief
Cigarettes and Coffee May Elevate Risk of Suicidal Behavior in Patients with Bipolar Disorder; Depression and Anxiety Have Different Effects on Risk of Mortality

Antipsychotics Decrease Mortality
Treatment with antipsychotics increases life expectancy for patients with schizophrenia.

On to 2010!
Dr. Alan Gelenberg reviews biological interventions approved during the past year, including new antipsychotics and a device to deliver repeated transcranial magnetic stimulation (rTMS).

INDEX
2009 Index

Iloperidone (Fanapt)
Iloperidone, an antipsychotic recently approved by the U.S. Food and Drug Administration (FDA), is comparable in efficacy to other second-generation agents.

INDEX

December 2009

Volume 32, 2009

Agitation, 39

Alcohol dependence, 8

Allopurinol (Lopurin and others), 6-7

Alzheimer's disease, 19-20, 34-35

Anticholinergic drugs, 43-44

Antidepressants, 24, 25, 44-45

Antipsychotics, 47-48

- in dementia, 25-26, 34-35

- long-acting, 9-10

- and mortality, 49-50

- second generation, 18, 21-22, 39

- side effects, 5-6

Anxiety disorders, 5, 9, 37-38, 38-40, 49

Attention-deficit/hyperactivity disorder, 44

Autism, 13-14

Behavioral risk factors, 7

Bipolar disorder

- allopurinol, 6-7, bipolar depression, 11

- children and adolescents, 37, 39

- contraception, 35

- mortality, 23

- volanzapine vs. divalproex, 2-3

- suicidal behavior, 49

Bleeding, gastrointestinal, 2

Bone mineral density, 27

Borderline personality disorder (BPD), 13, 46

Breast cancer, 30-31

Bupropion (Wellbutrin), 14-16

Caffeine, 19-20, 33-34, 49

Cannabinoid receptors, 3

Capsulotomy, 3-4

Cardiac adverse events, 12, 18

Chamomile, 37-38

Chelation therapy, 13-14

Children and adolescents, 5, 12, 23, 37, 39, 43

Cholinesterase inhibitors, 17-18, 48-49

Cingulotomy, 1

Coffee, 19-20, 49

Cognitive behavioral therapy (CBT), 5-6, 35, 43

Contraception, 35

Cytochrome P450 isoenzymes, 30-31

Deep brain stimulation (DBS), 1, 26-28

Dementia, 48-49

- anticholinergic medications, 43-44

- antipsychotics, 25-26, 34-35

- Ginkgo biloba, 28

- omega-3 fatty acids, 31

- prevention, 15, 19-20

- valproate, 39

Depression

- in adolescents, 43

- bone mineral density, 27

- deep brain stimulation, 26-28

- exercise, 41

- folate, 29-30

- and mortality, 49

- myocardial infarction, 44

- and Parkinson's disease, 31-32

- quetiapine, 38-40

- repetitive transcranial stimulation, 9

- treatment-resistant, 1

Dextroamphetamine, 33-34

Dietary supplements, 11

Dipyridamole (Persantine and others), 6-7

Divalproex (Depakote), 2-3

Donepezil (Aricept), 17-18

Dopamine, 44

Dosing, 44-45

Duloxetine (Cymbalta), 17

Elderly, 11, 23-24, 39, 43-44, 48-49

Estrogen, 7-8

Exercise, 15, 41

Fibromyalgia syndrome (FMS), 17, 42

Fish, 31

Folate, 29-30

Fractures, 23-24

Generalized anxiety disorder (GAD), 37-38, 38-40

Generic medications, 45

Ginkgo biloba, 19-20, 28

Hospitalization, psychiatric, 7

Hypertension, 15, 35-36

Illicit drug sales, 7

Iloperidone (Fanapt), 47-48

Injection site reactions, 8

Insomnia, 35

Internet, 7, 35

L-methylfolate (Deplin), 29-30

Lamotrigine (Lamictal), 11, 46

Leucotomy, 1

Lithium, 31

Melatonin, 15

Memantine (Namenda), 19

Metabolic effects, 34-35

Milnacipran (Savella), 17, 42

Minocycline (Solodyn and others), 16

Modafinil (Provigil), 19

Mortality, 7, 49

Myocardial infarction, 44

Naltrexone (Vivitrol), 8

Neurosurgery, 1, 3-4

Obesity, 3

Obsessive compulsive disorder (OCD), 3-4, 33-34

Olanzapine (Zyprexa), 2-3, 39

Olanzapine pamoate, 9-10

Omega-3 fatty acids, 31-32

Osteoporosis, 23-24

Pain syndromes, 17

Parkinson's disease, 31-32

Paroxetine (Paxil and others), 44-45

Polypharmacy, 11

Preeclampsia, 35-36

Pregabalin (Lyrica), 17

Pregnancy, 12, 33, 35-36

Psychosis, 10-12

QTc prolongation, 12

Quetiapine (Seroquel), 38-40

Repetitive transcranial magnetic stimulation (rTMS), 9

Rimonabant, 3

Schizophrenia, 49-50

- adjunctive estrogen, 7-8

- children and adolescents, 39

- donepezil, 17-18

- minocycline, 16

- modafinil, 19

- repetitive transcranial magnetic stimulation, 9

- vitamin D deficiency, 27, 39, 49-50

Selective serotonin reuptake inhibitors (SSRIs)

- dosing, 44-45

- elderly, 23-24

- gastrointestinal bleeding, 2

- pregnancy, 12, 35-36

Sertraline (Zoloft and others), 5, 44

Smoking, 14-16, 49

Stereotactic ablative surgery, 1

Suicide, 23, 31, 49

Sweating, 24

Syncope, 48-49

Tamoxifen, 30-31

Taranabant, 3

Tea, 19-20

Teratogenicity, 33, 35

Terazosin (Hytrin and others), 24

Valproate (Depakote and others), 33, 39

Varenicline (Chantix), 14-16

Venlafaxine (Effexor), 2

Vitamin D, 27

Weight gain, 5-6, 34-35

Weight loss, 3

Ziprasidone (Geodon), 39