Divalproex for Mania in Children and Adolescents: A Negative Study
The first double-blind study of divalproex (Depakote) in pediatric patients with bipolar disorder found no greater efficacy than placebo.
A double-blind study suggests efficacy for chamomile as an alternative treatment for anxiety.
Quetiapine for GAD and MDD
In a variety of studies, quetiapine (Seroquel) was found to be effective in treating generalized anxiety and major depressive disorders.
Valproate Does Not Improve Agitation in Patients with Dementia; Three More Atypical Antipsychotics May Be Approved for Pediatric Patients
Child and Adolescent Topics
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Although preparations of valproate (Depakote and others) have been used for at least the past decade to treat agitation in elderly patients with dementia, there is little evidence that valproate provides benefit for this indication (BTP 2008;31:35-36). A 2004 systematic review of three randomized,…