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August 2009

Folate and Depression
L-methylfolate (Deplin) shows theoretical promise as an augmenting strategy for treatment-resistant depression, but so far there is little clinical evidence of its efficacy.

In Brief
Lithium in Drinking Water May Decrease Suicide Risk; No Association Found Between Fish Consumption and Dementia

Breast Cancer, Tamoxifen, and 2D6 Inhibitors
Antidepressants and other drugs that inhibit the cytochrome P450 2D6 isoenzyme may cause low levels of tamoxifen in women with breast cancer.

Treating Depression in Parkinson's Disease
Two studies provide preliminary but encouraging data about nortriptyline and omega-3 fatty acids as potential treatments for depression in patients with Parkinson's disease.

Treating Depression in Parkinson's Disease

August 2009

Parkinson's disease (PD) is the second most prevalent neurodegenerative illness in the United States, afflicting about 1 million people.1 The classic motor triad of PD is tremor, rigidity, and bradykinesia. Common nonmotor features of PD are depression, dementia, drug-induced psychosis,…

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