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IN THIS ISSUE:
August 2009

Folate and Depression
L-methylfolate (Deplin) shows theoretical promise as an augmenting strategy for treatment-resistant depression, but so far there is little clinical evidence of its efficacy.

In Brief
Lithium in Drinking Water May Decrease Suicide Risk; No Association Found Between Fish Consumption and Dementia

Breast Cancer, Tamoxifen, and 2D6 Inhibitors
Antidepressants and other drugs that inhibit the cytochrome P450 2D6 isoenzyme may cause low levels of tamoxifen in women with breast cancer.

Treating Depression in Parkinson's Disease
Two studies provide preliminary but encouraging data about nortriptyline and omega-3 fatty acids as potential treatments for depression in patients with Parkinson's disease.

Breast Cancer, Tamoxifen, and 2D6 Inhibitors

August 2009

Each year, approximately 180,000 women in the United States are diagnosed with invasive breast cancer.1 Even though breast cancer incidence and deaths have been declining recently, breast cancer claimed about 40,000 lives in 2008 in the United States.2 Roughly 75% of women with…

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