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August 2009

Folate and Depression
L-methylfolate (Deplin) shows theoretical promise as an augmenting strategy for treatment-resistant depression, but so far there is little clinical evidence of its efficacy.

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Antidepressants and other drugs that inhibit the cytochrome P450 2D6 isoenzyme may cause low levels of tamoxifen in women with breast cancer.

Treating Depression in Parkinson's Disease
Two studies provide preliminary but encouraging data about nortriptyline and omega-3 fatty acids as potential treatments for depression in patients with Parkinson's disease.

Folate and Depression

August 2009

Considerable interest has been generated lately in the topic of folate and depression and, more specifically, in the role of L-methylfolate (Deplin) for modulating trimonoamines and augmenting antidepressants.1 L-methylfolate is available in the United States by prescription as a "medicinal…

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