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May 2009

Treating Fibromyalgia
Antidepressants offer some relief for sufferers of fibromyalgia.

Donepezil in Schizophrenia?
A recent report suggests donepezil (Aricept) does not appear to benefit cognitive symptoms of schizophrenia.

Second-Generation Antipsychotics and the Risk of Cardiac Death
Second-generation antipsychotics produce about the same level of cardiac risks as first-generation agents.

Preventing Dementia
Higher levels of education, mentally challenging work, and moderate coffee consumption may protect against Alzheimer’s disease, but Ginkgo biloba does not.

In Brief
Mixed Results for Modafinil as an Adjunct in Schizophrenia; Memantine Not Efficacious as an Adjunct in Schizophrenia

Second-Generation Antipsychotics and the Risk of Cardiac Death

May 2009

Some first-generation antipsychotic drugs block repolarizing potassium currents in vitro and prolong the QT interval, which can cause ventricular tachyarrhythmias and sudden cardiac death.1 Thioridazine (Mellaril and others) now carries a black-box warning about this. Is the risk of cardiac…

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