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IN THIS ISSUE:
April 2009

Medication Treatment for BPD: The Limited Evidence Base
Antipsychotics, especially olanzapine (Zyprexa), may be beneficial in treating borderline personality disorder, but the data are limited and mixed.

Chelation Therapy for Autism?
A study of chelation therapy for autism was stopped due to potential adverse effects.

Varenicline for Smoking Cessation
Varenicline (Chantix) should be used with caution in psychiatric patients attempting to quit smoking.

Minocycline for Schizophrenia: Preliminary Results
The results from an open-label study of minocycline (Solodyn and others) suggest benefit in the treatment of schizophrenia.

In Brief
Modifying risk factors can help prevent dementia; Increased lighting improves cognition in elderly

Minocycline for Schizophrenia: Preliminary Results

April 2009

One of the most brain-penetrable of the tetracyclines, minocycline (Solodyn and others) has anti-inflammatory and neuroprotective effects that appear unrelated to its antimicrobial action. In mouse models of Huntington's disease and amyotrophic lateral sclerosis, minocycline delays mortality or disease…

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