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January 2009

Invasive Treatments for Resistant Depression
Neurosurgical procedures may be efficacious for some people with severe treatment-resistant depression, but they may cause serious adverse events.

SSRIs Associated with GI Bleeding
Serotonin reuptake inhibitors appear to increase the risk of serious bleeding in some patients.

Treating Mild Mania: Olanzapine versus Divalproex
In a double-blind, placebo-controlled study, olanzapine (Zyprexa) was superior to divalproex (Depakote) for the treatment of mania, but caused more discontinuations due to adverse effects, such as weight gain.

In Brief
Rimonabant Development Discontinued

Treatment-Refractory OCD: A Role for Neurosurgery?
In a case series in Sweden, capsulotomy improved symptoms of obsessive compulsive disorder in treatment-refractory patients but caused serious adverse events.

SSRIs Associated with GI Bleeding

January 2009

Selective serotonin reuptake inhibitors (SSRIs) appear to deplete platelets of serotonin and impair platelet aggregation, which can lead to pathological bleeding (BTP 2007;30:47-48, 2005;28:9). Epidemiologic studies support the association of SSRIs and an increased risk of upper gastrointestinal…

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