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November 2008

Metformin for Antipsychotic-Associated Weight Gain
Most studies with metformin (Avandamet and others) suggest that it attentuates weight gain or actually promotes weight loss in patients who are taking antipsychotics.

In Brief
Valproate Teratogenicity Increased by High Dose, Concomitant Drugs;Celecoxib, Naproxen Do Not Protect Against Alzheimer's Disease

Atomoxetine versus Methylphenidate for Pediatric ADHD
Methylphenidate (Ritalin and others) appears to be more efficacious than atomoxetine (Strattera) for treating attention-deficit/hyperactivity disorder in children but has more adverse effects.

Rivastigmine (Exelon) Patch
A transdermal system for delivering rivastigmine (Exelon) is now available in the United States for treating dementia associated with Alzheimer's or Parkinson's disease.

Metformin for Antipsychotic-Associated Weight Gain

November 2008

Many people taking antipsychotic agents gain weight,1 which adds to the morbidity and mortality already associated with chronic mental illness. Metformin (Avandamet and others) is one of an increasing number of drugs prescribed to combat weight gain with antipsychotic medication. Indicated…

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