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IN THIS ISSUE:
September 2008

Valproate for Agitation in Dementia
In two studies, valproate (Depakote and others) did not seem to decrease agitation and aggression in patients with dementia.

Topiramate in the Treatment of Borderline Personality Disorder
Preliminary research suggests topiramate may be useful in the treatment of borderline personality disorder.

In Brief
Generic Risperidone Now Available; Ginkgo biloba Not Effective for Dementia; Autism Linked to Defects in “Learning” Genes

Quetiapine Augmentation in GAD: A Negative Trial
In a recent study, augmenting paroxetine (Paxil and others) treatment of generalized anxiety disorder with quetiapine (Seroquel) was ineffective.

BTP Announces ASCP Partnership
BTP proudly announces our partnership with the American Society of Clinical Psychopharmacology (ASCP) and extends a warm welcome to all ASCP members.

ECGs for Kids with ADHD?
An electrocardiogram may be advisable for some children before they begin pharmacologic treatment for attention-deficit/hyperactivity disorder.

Quetiapine Augmentation in GAD: A Negative Trial

September 2008

In February (BTP 2008;31:6-8), we presented results of a double-blind trial by Chouinard and collaborators, who compared extended-release quetiapine (Seroquel XR) monotherapy, 50 or 150 mg/day; paroxetine (Paxil and others), 20 mg/day; and placebo for 8 weeks in patients with generalized anxiety…

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