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IN THIS ISSUE:
January 2008

Treating Behavioral Problems in Dementia
No drug is clearly efficacious for behavioral problems in dementia, and all are associated with significant risks.

Prolactin Elevation and Antipsychotics
Risperidone (Risperdal) seems to increase prolactin more than conventional and other second-generation antipsychotics; adjunctive aripiprazole (Abilify) may lower antipsychotic-induced hyperprolactinemia.

In Brief
Atomoxetine Effective for ADHD in Preschool Children; Excessive Body Weight Increases Risk of Dementia

Treating Adolescent Mania
Olanzapine (Zyprexa) effectively treats adolescent bipolar disorder but appears to cause harmful medical consequences in young patients.

Isotretinoin and Depression
Depression is a possible side effect of treatment with isotretinoin (Accutane and others).

Treating Adolescent Mania

January 2008

A carefully designed study demonstrated the good, the bad, and the uncertain in the treatment of adolescents with bipolar mania. Tohen and others enrolled 161 patients, 13 to 17 years old, with an acute manic or mixed episode in a 3-week, double-blind, randomized trial.1 Subjects received…

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